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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 07 Oct 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

The effect of morphine and naloxone administration on plasma oxytocin concentrations in the first stage of labour. Clin Endocrinol (Oxf) 1992 Oct;37(4):349-53

Author(s) :

Lindow SW, van der Spuy ZM, Hendricks MS, Rosselli AP, Lombard C, Leng G.

Year of publication :


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Résumé (français)  :

Abstract (English)  :

(Department of Obstetrics and Gynaecology, University of Cape Town, South Africa.)

OBJECTIVE: We investigated the effect of an opiate (morphine) and an opiate antagonist (naloxone) on the maternal secretion of oxytocin in the first stage of labour.

DESIGN: Patients were randomized to receive either morphine 5 mg (n = 9), naloxone 1.2 mg (n = 10) or sterile water (n = 9) which was injected intravenously.

PATIENTS: Healthy women in the first stage of labour between 3 and 6 cm dilated with no prior analgesia or oxytocin administration were recruited for the study.

MEASUREMENTS: Peripheral maternal oxytocin levels were measured by radioimmunoassay for 15 minutes before and 15 minutes after administration of the assigned substance. Sampling was at 2.5 minute intervals.

RESULTS: Significant reduction in the mean oxytocin concentration was found in the patients who received morphine (-2.62 pmol/l/sample) but no change was found in the naloxone group (+0.57 pmol/l/sample) when compared with controls (+0.64 pmol/l/sample).

CONCLUSION: Maternal oxytocin secretion is inhibited by exogenous opiates in the first stage of labour while an effect of opiate antagonism was not demonstrated.

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Keywords :

➡ hormones ; oxytocin ; pain

Author of this record :

Bernard Bel — 07 Oct 2004

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