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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 16 Nov 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Circulating levels of inhibin A, inhibin B and activin A in normal and intrauterine growth restricted (IUGR) fetuses. European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;117(1):38-44.

Author(s) :

Morpurgo PS, Cetin I, Borgato S, Cortelazzi D, Nobile-DeSantis MS, Vaghi I, Beck-Peccoz P.

Year of publication :


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Résumé (français)  :

Abstract (English)  :

Objective: To evaluate the relationships between circulating levels of inhibin A, inhibin B and activin A, and sex, gestational age and gonadotropins in normal and pathological fetuses.

Study design: The study included 31 normal fetuses and 12 affected with intrauterine growth restriction (IUGR) of gestational age ranging 20–40 weeks.

Results: No gender difference in inhibin A and activin A levels were observed. Inhibin B levels were significantly higher in males than in females (P<0.05). Fetuses with the highest levels of inhibin A and B were found in the IUGR group that also showed activin A levels significantly higher than normal. No correlations were observed between inhibin A, inhibin B, activin A and both gonadotropins.

Conclusion: Plasma inhibin A, inhibin B and activin A are detectable in both genders during intrauterine life. The different gender pattern of inhibin B suggests that inhibin B may contribute to the assessment of the hypothalamic–pituitary–gonadal set-point at least in males.

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Keywords :

➡ physiology ; hormones ; foetus growth ; low birth weight

Author of this record :

Cécile Loup — 16 Nov 2004

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