Choose your font:
 Mukta Malar
 Open Sans Condensed
 Source Sans Pro


[Valid RSS] RSS

Database - Alliance francophone pour l'accouchement respecté (AFAR)

Description of this bibliographical database (AFAR website)
Currently 3106 records
YouTube channel (tutorial)

Created on : 17 Nov 2004
Modified on : 01 Dec 2007

 Modify this record
Do not follow this link unless you know an editor’s password!

Share: Facebook logo   Tweeter logo   Hard

Bibliographical entry (without author) :

Efficacy and safety of a new, chromatographically purified rhesus (D) immunoglobulin. European Journal of Obstetrics & Gynecology and Reproductive Biology 2004;117(2):154-161.

Author(s) :

MacKenzie IZ, Bichler J, Mason GC, et al.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

Objectives: To study the efficacy, safety, and tolerability of the 300 g dose of a new chromatographically produced rhesus immunoglobulin (Rhophylac® 300) for ante- and postnatal rhesus prophylaxis.

Design: In an open-label multi-centre study, rhesus D (RhD)-negative women were randomly allocated to receive Rhophylac® 300 either intravenously or intramuscularly at the 28th week of gestation and within 72 h after delivery of an RhD-positive child. Serum samples were obtained prior to the antenatal dose and 6–11.5 months after delivery of an RhD-positive child and tested by the indirect antiglobulin test and papain test for anti-D. Safety parameters were assessed in all women who were treated with the study drug.

Results: Four hundred and thirty two women received the study drug antenatally. No differences were detected in efficacy or tolerability between intravenous and intramuscular administration. Of the 261 women who delivered an RhD-positive child and received rhesus prophylaxis according to the protocol, 248 women returned for follow-up investigations. None of them had detectable anti-D at their last visit. There were no serious adverse events, no cases of infectious disease transmission nor clinically relevant changes in laboratory safety values and vital signs attributable to the study drug.

Conclusions: The results suggest that Rhophylac® 300 given intravenously or intramuscularly is safe and efficacious in preventing rhesus (D) immunisation.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ antenatal diagnosis

Author of this record :

Cécile Loup — 17 Nov 2004

Discussion (display all languages)
➡ Only identified users

 I have read the guidelines of discussions and I accept all terms (read guidelines)


New expert query --- New simple query

Creating new record --- Importing records

User management --- Dump database --- Contact


This database is managed by Alliance francophone pour l'accouchement respecté (AFAR,
affiliated with Collectif interassociatif autour de la naissance (CIANE,
It is fed by the voluntary contributions of persons interested in the sharing of scientific data.
If you agree with this project, you can support us in several ways:
(1) contributing to this database if you have a minimum training in documentation
(2) or financially supporting AFAR (see below)
(3) or joining the AFAR (or another society affiliated with CIANE).
Sign in or create an account to follow changes or become an editor.
Contact afar.association(arobase) for more information.

Valid CSS! Valid HTML!
Donating to AFAR (click “Faire un don”) will help us to maintain and develop sites and public
databases towards the support of parents and caregivers’ informed decisions with respect to childbirth