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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Currently 3076 records
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Created on : 02 Dec 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Letter. Epidemiology of preterm birth. Authors’ reply. The British Medical Journal 2004;329:1287.

Author(s) :

Tucker J, McGuire W.

Year of publication :


URL(s) :…

Résumé (français)  :

Voir avant fiches 1070 et 1069.

Abstract (English)  :

EDITOR—In noting antenatal steroids and exogenous surfactants as two specific perinatal interventions that have contributed to trends in improved outcomes for very preterm infants, Hutchon thinks that we have omitted to include delayed cord clamping. We argue that whereas there is robust evidence from larger trials and systematic reviews for both prophylactic steroids and surfactants,1 2 there is currently continued uncertainty in the published evidence base about the effect of delayed cord clamping on mortality and disability outcomes.

The recently published Cochrane review of this intervention identifies seven trials in which a total of 297 infants participated.3 There is some evidence from meta-analysis of data from these trials that delayed cord clamping results in fewer infants receiving blood transfusions in the neonatal period, but there is little other evidence of benefit. Infants in the delayed clamping group had higher peak serum bilirubin concentration in the early neonatal period. There is insufficient evidence of effect on mortality, respiratory outcomes, the incidence of severe intraventricular haemorrhage or periventricular leucomalacia, or the incidence of necrotising enterocolitis.3 Most importantly, there are not yet any data on the effect of this intervention on neurodevelopmental outcomes in the longer term. Further large trials are needed to provide these data in order to clarify whether the practice of delayed cord clamping for very preterm infants should be adopted.

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Keywords :

➡ pathologies of newborn ; low birth weight ; premature baby ; newborn care

Author of this record :

Cécile Loup — 02 Dec 2004

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