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Database - Alliance francophone pour l'accouchement respecté (AFAR)

Description of this bibliographical database (AFAR website)
Currently 3053 records
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Created on : 24 Oct 2005
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Screening test for preeclampsia through assessment of uteroplacental blood flow and biochemical markers of oxidative stress and endothelial dysfunction.{Chili}. Am J Obstet Gynecol. 2005 Oct;193(4):1486-91.

Author(s) :

Parra M, Rodrigo R, Barja P, Bosco C, Fernandez V, Munoz H, Soto-Chacon E.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: This study was undertaken to evaluate whether screening through a uterine artery (UtA) Doppler and biochemical markers of oxidative stress and endothelial dysfunction predict preeclampsia.

STUDY DESIGN: UtA Doppler was performed at 11 to 14 and 22 to 25 weeks on 1447 asymptomatic pregnant women. Oxidative stress, endothelial dysfunction, and antiangiogenic state were assessed in women who later developed preeclampsia and normotensive controls.

RESULTS: There was a significantly increased of UtA pulsatility index (PI), plasma levels of soluble fms-like tyrosine kinase 1 (sFlt1), PAI-1/PAI-2 ratio, and F-2 isoprostane in women who subsequently developed preeclampsia compared with control pregnancies. Multivariate logistic regression showed that increased UtA PI performed at 23 weeks was the best predictor for preeclampsia.

CONCLUSION: This study demonstrates early changes in markers of impaired placentation, antiangiogenic state, oxidative stress, and endothelial dysfunction suggesting that these derangements may play a role in the pathogenesis of preeclampsia. Our data point to UtA as the best test to predict preeclampsia at 23 weeks of gestation.

Sumário (português)  :

Comments :

Argument (français) :

L’echo doppler sur les artères utérines autour de 23 semaines permettrait de prédire assez surement les risques de pré-éclampsie.

Argument (English):

Argumento (português):

Keywords :

➡ evidence-based medicine/midwifery ; antenatal diagnosis ; eclampsia (pre-)

Author of this record :

Cécile Loup — 24 Oct 2005

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