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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 28 Mar 2006
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Misoprostol use for labor induction in developing countries: a prospective study in Guinea. Eur J Obstet Gynecol Reprod Biol. 2005 Sep 1;122(1):40-4.

Author(s) :

Yolande H, Namory K, Delphine F, Mamadou Hady D, Mamadou Dioulde B, Daniel T, Patrick T.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

BACKGROUND: The purpose of this study was to assess the efficacy, side effects and cost of misoprostol regimens in various obstetrical situations frequently occurring in developing countries.

STUDY DESIGN: One hundred and four parturient women with indications for labor induction received different regimens of misoprostol in the range of 50-800 microg according to their gestational age. Misoprostol was administered by the vaginal route, every 6h without exceeding four doses.

RESULTS: All indications for labor induction concerned women with a gestational age of more than 30 weeks, except in the intrauterine death cases. The mean overall duration of labor was 7.8 h (+/-4.6 h). The mean amount of misoprostol used was 226 microg (+/-196 microg). The difference in the mean labor duration between the four indications for induction was statistically significant (P<0.01). It was also significant for the mean total dose of misoprostol used. Total dose of misoprostol and Bishop score were inversely proportional. Two caesarean deliveries and two uterine ruptures were recorded, but no maternal deaths. The mean Apgar score was 8.0 (+/-1) at 1 min and 9.5 (+/-0.8) at 5 min. In our series, four fetal deaths occurred. The mean cost of misoprostol for labor induction was around US$ 1, with a range of 0.05-4.

CONCLUSIONS: The use of vaginal misoprostol appears to be relevant in developing countries in cases where labor induction is indicated. Nevertheless, the advantages of misoprostol (low cost, facility of storage) are counter-balanced by side-effects (C-section, uterine rupture) which can be harmful for the mother and also for the newborn.

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Resumen (español)  :

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Argument (English):

Argumento (português):

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Keywords :

➡ c-section/caesarean ; evidence-based medicine/midwifery ; induction of labor ; misoprostol (Cytotec) ; perinatal death rates ; maternal age ; post-term pregnancy

Author of this record :

Cécile Loup — 28 Mar 2006

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