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Database - Alliance francophone pour l'accouchement respecté (AFAR)

Description of this bibliographical database (AFAR website)
Currently 3059 records
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Created on : 28 Mar 2006
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Randomized trial in multiparous patients: investigating a single vs. two-dose regimen of intravaginal misoprostol for induction of labor.{UK}. Acta Obstet Gynecol Scand. 2003 Feb;82(2):138-42.

Author(s) :

Lokugamage AU, Forsyth SF, Sullivan KR, El Refaey H, Rodeck CH.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

BACKGROUND: Multiparous patients have a higher risk of hyperstimulation and uterine rupture than nulliparous patients. The minimum possible dose of uterotonic drug should be used in induction of labor for multiparous patients to avoid excessive uterine activity, which could increase both maternal and fetal risks.

METHODS: One hundred and four women were randomized to either a single dose of 50 micro g of intravaginal misoprostol in 24 h, or two consecutive doses of intravaginal 50 micro g misoprostol 6 h apart.

RESULTS: The mean induction to delivery interval (789 min [95% CI: 637-941] vs. 576 min [95% CI: 484-667], p = 0.018) and delivery rate within 12 h (63% vs. 83%, p = 0.035) were higher in the two-dose group. The oxytocin augmentation rate (14% vs. 2%, p = 0.03) was higher in the single-dose group. There was a higher rate of clinician input related to suspicious cardiotocographic readings in the single-dose arm (p = 0.04). There was no statistical difference (p > 0.05) between the one- and two-dose regimens with respect to the rates of tachysystole (21% vs. 15%), hyperstimulation (3.9% vs. 0%), and meconium staining at delivery (9.8% vs. 13.2%).

CONCLUSIONS: The two-dose regimen was most efficient, but both regimens were well tolerated by the fetuses.

Sumário (português)  :

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Argument (français) :

Argument (English):

Argumento (português):

Keywords :

➡ evidence-based medicine/midwifery ; induction of labor ; fetal distress ; misoprostol (Cytotec) ; oxytocin ; post-term pregnancy

Author of this record :

Cécile Loup — 28 Mar 2006

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