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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 26 Sep 2006
Modified on : 01 Dec 2007

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Bibliographical entry (without author) :

Elevated second trimester serum homocysteine levels in women with gestational diabetes mellitus. {Turquie}. Archives of Gynecology and Obstetrics 2006;274(6):333-337.

Author(s) :

Guven MA, Kilinc M, Batukan C, Ekerbicer HC, Aksu T.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: Our aim was to investigate the association between total serum homocysteine, vitamin B12 and folate levels in pregnant women with gestational diabetes mellitus (GDM), glucose intolerance and compare them with those of glucose tolerant pregnant women.

MATERIALS AND METHODS: Serum homocysteine, vitamin B12 and serum folate levels were prospectively measured in a total of 223 pregnant women who were grouped according to their status of glucose tolerance as gestational diabetes (abnormal 1-h and 3-h glucose tolerance test; n = 30), glucose intolerant (abnormal 1-h, but normal 3-h glucose tolerance test; n = 46) or normal controls (normal 1-h glucose test; n = 147).

RESULTS: Mean serum homocysteine concentration of women in gestational diabetes, glucose intolerants and normal controls at 24–28 weeks of gestation was 9.0 ± 3.1, 8.1 ± 2.5 and 7.4 ± 1.6 μmol/l, respectively. The only statistically difference in homocysteine levels was observed between women with gestational diabetes and normal controls (P < 0.01). However, no difference was observed for vitamin B12 and folate levels.

CONCLUSION: Second trimester serum homocysteine concentrations are higher among women with GDM, as compared to normal controls.

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Keywords :

➡ gestational diabetes

Author of this record :

Cécile Loup — 26 Sep 2006

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