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Bibliographical entry (without author) : | Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science. 2006 Dec 15;314(5806):1788-92. |
Author(s) : | Tyzio R, Cossart R, Khalilov I, Minlebaev M, Hubner CA, Represa A, Ben-Ari |
Year of publication : | 2006 |
URL(s) : | |
Résumé (français) : | Comment le foetus se prépare-t-il à l’accouchement ? |
Abstract (English) : | We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, {gamma}-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were triggered by oxytocin, an essential maternal hormone for labor. In vivo administration of an oxytocin receptor antagonist before delivery prevented the switch of GABA actions in fetal neurons and aggravated the severity of anoxic episodes. Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery. |
Sumário (português) : |
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Comments : | Voir aussi : |
Argument (français) : | La mère informe et prépare les neurones du foetus à l’accouchement grâce à l’ocytocine… (Expérimentation sur des rats) |
Argument (English): | We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. |
Argumento (português): |
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Keywords : | ➡ physiology ; induction of labor ; oxytocin ; post-term pregnancy |
Author of this record : | Bernard Bel — 11 Jan 2007 |
Discussion (display only in English) | ||
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