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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Currently 3059 records
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Created on : 22 Dec 2003
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

A comparison of 100 microg oral misoprostol every 3 hours and 6 hours for labor induction: a randomized controlled trial. J Obstet Gynaecol Res. 2002 Dec;28(6):308-12.

Author(s) :

Pongsatha S, Sirisukkasem S, Tongsong T.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: To compare the efficacy and safety of 100 microg oral misoprostol for induction of labor between the regimen of 3 hour and 6 hour interval administration.

METHODS: Singleton pregnancies indicated for induction of labor between 34 and 42 weeks of gestation in the condition of unfavorable cervix (Bishop score < or = 4) and no contraindication for prostaglandins therapy were recruited into the study. All pregnant women were randomly assigned to receive 100 microg oral misoprostol every 3 hours or 6 hours until the cervix was favorable for amniotomy, spontaneous rupture of membranes or active labor occurred.

RESULTS: The mean time interval from induction to vaginal delivery was significantly shorter in the 3 hour interval group, compared with the 6 hour interval group (13.82 +/- 6.98h and 17.66 +/- 7.48h, P = 0.0019). There was no significant difference between the groups with regard to mode of delivery, analgesic requirement, maternal complication and neonatal outcome.

CONCLUSIONS: 100 microg oral misoprostol every 3 hours is more effective for labor induction than every 6 hours but there was no difference in mode of delivery, analgesic requirement, maternal complications and neonatal outcome. A dose of 100 microg misoprostol orally every 3 hours seems to be the optimum regimen and the new option for labor induction. However, further study should be performed.

Sumário (português)  :

Comments :

Argument (français) :

Le dosage optimal du misoprostol pour un déclenchement

Argument (English):

Argumento (português):

Keywords :

➡ physiology ; induction of labor ; rupture of membranes ; amniotomy ; active management of labor ; post-term pregnancy ; misoprostol (Cytotec)

Author of this record :

Cécile Loup — 22 Dec 2003
➡ latest update : Bernard Bel — 02 Dec 2007

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