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Created on : 09 Jul 2018
Modified on : 10 Jul 2018

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Bibliographical entry (without author) :

Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial. The Amercian Journal of psychiatry. 2018

Author(s) :

Alain Brunet, Daniel Saumier, Aihua Liu, David L. Streiner, Jacques Tremblay, Roger K. Pitman

Year of publication :

2018

URL(s) :

https://ajp.psychiatryonline.org/doi/abs/10.1176/a…
https://doi.org/10.1176/appi.ajp.2017.17050481

Résumé (français)  :

Abstract (English)  :

Objective:

The authors assessed the efficacy of trauma memory reactivation performed under the influence of propranolol, a noradrenergic beta-receptor blocker, as a putative reconsolidation blocker, in reducing symptoms of posttraumatic stress disorder (PTSD).
Method:

This was a 6-week, double-blind, placebo-controlled, randomized clinical trial in 60 adults diagnosed with long-standing PTSD. Propranolol or placebo was administered 90 minutes before a brief memory reactivation session, once a week for 6 consecutive weeks. The hypothesis predicted a significant treatment effect of trauma reactivation with propranolol compared with trauma reactivation with placebo in reducing PTSD symptoms on both the Clinician-Administered PTSD Scale (CAPS) and the patient-rated PTSD Checklist–Specific (PCL-S) in an intention-to-treat analysis.
Results:

The estimated group difference in posttreatment CAPS score, adjusted for pretreatment values (analysis of covariance), was a statistically significant 11.50. The within-group pre- to posttreatment effect sizes (Cohen’s d) were 1.76 for propranolol and 1.25 for placebo. For the PCL-S, the mixed linear model’s estimated time-by-group interaction yielded an average decrease of 2.43 points per week, for a total significant difference of 14.58 points above that of placebo. The pre- to posttreatment effect sizes were 2.74 for propranolol and 0.55 for placebo. Per protocol analyses for both outcomes yielded similar significant results.
Conclusions:

Pre-reactivation propranolol, a treatment protocol suggested by reconsolidation theory, appears to be a novel and efficacious treatment for PTSD. Replication studies using a long-term follow-up in various trauma populations are required.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Etude sur les effets de la prise d’un bêta-bloquant couplé à une thérapie cognitive dans le traitement du stress post traumatique chronique. Résultats encourageants qui seront testés lors d’une plus vaste étude sur une population attendue de 400 personnes en France.

Argument (English):

Pre-reactivation propranolol, a treatment protocol suggested by reconsolidation theory, appears to be a novel and efficacious treatment for PTSD. Replication studies using a long-term follow-up in various trauma populations are required.

Argumento (português):

Estudo dos efeitos da administração de um betabloqueador associado à terapia cognitiva no tratamento do estresse crônico pós-traumático. Incentivar resultados que serão testados em um estudo maior sobre uma população esperada de 400 pessoas na França.

Argumento (español):

Keywords :

➡ post-traumatic stress

Author of this record :

Alison Passieux — 09 Jul 2018
➡ latest update : Bernard Bel — 10 Jul 2018