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Database - Alliance francophone pour l'accouchement respecté (AFAR)

Description of this bibliographical database (AFAR website)
Currently 3106 records
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Created on : 19 Jan 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Vaginal administration of the nitric oxide donor isosorbide mononitrate for cervical ripening at term: a randomized controlled study. American Journal of Obstetrics and Gynecology 2003;189(6):1692-1697.

Author(s) :

Ekerhovd E, Bullarbo M, Andersch B, Norström A.

Year of publication :


URL(s) :

Résumé (français)  :

Abstract (English)  :

OBJECTIVE : Our aim was to examine the effect of the nitric oxide donor isosorbide mononitrate on the uterine cervix at term and to evaluate possible adverse effects of this treatment.

STUDY DESIGN : Term pregnant women were randomly selected to receive either 40 mg vaginally administered isosorbide mononitrate or placebo 4 hours before elective cesarean section. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate, umbilical arterial Doppler indices, and various side effects were examined.

RESULTS : Isosorbide mononitrate induced a significant increase in cervical distensibility. It also caused a significant change in maternal blood pressure and maternal pulse rate. In addition, the frequency of maternal headache and palpitations was significantly higher in the isosorbide mononitrate group versus the placebo group. However, the intensity of these symptoms was moderate.

CONCLUSION : Vaginal administration of 40 mg of isosorbide mononitrate induces cervical ripening at term. Although the majority of women experienced side effects, no serious clinical maternal or fetal adverse effects, resulting in specific medication or emergency cesarean section, were diagnosed.

Sumário (português)  :

Resumen (español)  :

Comments :

Argument (français) :

Etude randomisée de l’administration vaginale de mononitrate isosorbide pour la maturation du col.

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ physiology ; induction of labor ; ripening of cervix ; post-term pregnancy

Author of this record :

Cécile Loup — 19 Jan 2004
➡ latest update : Bernard Bel — 02 Dec 2007

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