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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 11 Feb 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

An Amniotic Fluid Index 5 cm Within 7 Days of Delivery in the Third Trimester Is Not Associated with Decreasing Umbilical Arterial pH and Base Excess. Journal of Perinatology 2004;24(2):72-76.

Author(s) :

Driggers RW, Holcroft CJ, Blakemore KJ, Graham EM.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :


To determine if an amniotic fluid index (AFI) 5.0 cm within 7 days of delivery in the third trimester is associated with decreasing umbilical arterial pH and base excess.


Cases for this retrospective cohort study were all pregnancies 26 weeks with intact membranes and an AFI 5.0 cm within 7 days of delivery between 11/99 and 7/02. Multiple gestations, aneuploid, and anomalous fetuses were excluded. Controls with an AFI >5.0 cm within 7 days of delivery were matched to each case within 1 week by gestational age. For a control group with a mean±SD umbilical arterial pH of 7.26±0.07 and =0.05, a sample size of 100 would have a power of 99% to detect a difference with a study group whose mean was 7.20. Data were compared using paired Student’s t-test, Mann-Whitney, Fisher’s exact, 2 and risk ratios with 95% confidence intervals.


In all, 131 neonates with an AFI 5.0 cm were matched to 131 controls with an AFI >5 cm. There was no difference in gestational age (37.6±3.0, 37.7±3.0 weeks) or birth weight (2897±810, 2762±788 g). There was no difference in umbilical artery pH (7.25±0.07, 7.26±0.07) or base excess (-3.32±2.59, -2.83±2.45 mmol/l), even in small for gestational age (SGA) infants in both groups. There was no difference in the number of SGA neonates, 5-minute Apgar <7, respiratory distress syndrome, necrotizing enterocolitis, or neurologic morbidity. Linear regression showed no correlation between AFI and either umbilical arterial pH (r=-0.00047, SE=0.001, p=0.63) or base excess (r=-0.029, SE=0.037, p=0.428).


An AFI 5.0 cm measured within 7 days of delivery in the third trimester is not associated with decreasing umbilical arterial pH and base excess.

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Keywords :

➡ evidence-based medicine/midwifery ; screening ; fetal distress ; morbidity

Author of this record :

Cécile Loup — 11 Feb 2004

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