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Database - Alliance francophone pour l'accouchement respecté (AFAR)

Description of this bibliographical database (AFAR website)
Currently 3059 records
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Created on : 26 Feb 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

A randomized trial of saline solution–moistened misoprostol versus dry misoprostol for first-trimester pregnancy failure. American Journal of Obstetrics and Gynecology 2004;190(2):389-394.

Author(s) :

Gilles JM, Creinin MD, Barnhar K, et al.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE : The purpose of this study was to estimate whether the efficacy of treatment with intravaginal misoprostol for first-trimester pregnancy failure is enhanced by the addition of saline solution.

STUDY DESIGN : Eighty women with embryonic/fetal death or anembryonic pregnancy were assigned randomly to receive either 800 g of misoprostol with saline solution (group I, 41 women) or without (group II, 39 women). Treatment was repeated on day 3 if the gestational sac remained. Curettage was performed if the gestational sac remained on day 8 or as necessary during at least 30 days of follow-up. Data were analyzed with the Student t test and the 2 or Fisher exact test.

RESULTS : By the first follow-up visit, 73% (group I) and 64% (group II) of women passed the gestational sac (P = .38). By the second follow-up visit, expulsion rates were 83% and 87%, respectively (P = .59). Five subjects in each group underwent curettage.

CONCLUSION : Misoprostol is effective for the treatment of failed first-trimester pregnancy. The expulsion rate is not improved by adding saline solution.

Sumário (português)  :

Comments :

Argument (français) :

Essai randomisé du misoprostol en solution humide ou sec pour la protection contre une interruption de grossesse au premier trimestre.

Argument (English):

Argumento (português):

Keywords :

➡ physiology ; induction of labor ; stillbirth ; post-term pregnancy ; misoprostol (Cytotec)

Author of this record :

Cécile Loup — 26 Feb 2004
➡ latest update : Bernard Bel — 02 Dec 2007

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