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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Currently 3076 records
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Created on : 30 Mar 2004
Modified on : 02 Dec 2007

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Bibliographical entry (without author) :

Mortality Following Blood Culture in Premature Infants: Increased with Gram-negative Bacteremia and Candidemia, but Not Gram-positive Bacteremia. Journal of Perinatalogy 2004;24(3):175-180.

Author(s) :

Benjamin DK, DeLong E, Cotten CM, Garges HP, Steinbach WJ, Clark RH.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

OBJECTIVE: To describe survival following nosocomial bloodstream infections and quantify excess mortality associated with positive blood culture.

STUDY DESIGN: Multicenter cohort study of premature infants.

RESULTS: First blood culture was negative for 4648/5497 (78%) of the neonates ı 390/4648 (8%) died prior to discharge. Mortality prior to discharge was 19% in the 161 infants with Gram-negative rod (GNR) bacteremia, 8% in the 854 neonates with coagulase negative staphylococcus (CONS), 6% in the 169 infants infected with other Gram-positive bacteria (GP-o), and 26% in the 115 neonates with candidemia. The excess 7-day mortality was 0% for Gram-positive organisms and 83% for GNR bacteremia and candidemia. Using negative blood culture as referent, GNR [hazard ratio (HR)=2.61] and candidemia (HR=2.27) were associated with increased mortality; CONS (HR=1.08) and GP-o (HR=0.97) were not.

CONCLUSIONS: Nosocomial GNR bacteremia and candidemia were associated with increased mortality but Gram-positive bacteremia was not.

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Keywords :

➡ infections ; premature baby

Author of this record :

Cécile Loup — 30 Mar 2004

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