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Database - Alliance francophone pour l'accouchement respecté (AFAR)

Description of this bibliographical database (AFAR website)
Currently 3032 records
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https://afar.info/id=746

Created on : 29 Apr 2004
Modified on : 01 Dec 2007

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Bibliographical entry (without author) :

Different levels of platelet activation in preeclamptic, normotensive pregnant, and nonpregnant women. American Journal of Obstetrics and Gynecology 2004;190(4):1128-1134.

Author(s) :

Holthe MR, Staff AC, Berge LN, Lyberg T.

Year of publication :

2004

URL(s) :

http://www.sciencedirect.com/science/article/B6W9P…

Résumé (français)  :

Abstract (English)  :

Objective

The aims of our study were to determine the basal platelet activation state in women with preeclampsia compared with normotensive pregnant women and nonpregnant women and to investigate the platelet reactivity on in vitro stimulation with adenosine diphosphate or thrombin receptor activation peptide.
Study design

Platelet expression of CD61 (fibrinogen receptor), CD42a (von Willebrand factor receptor), CD62P (P-selectin), CD63 (Glycoprotein 53), and PAC-1 binding (activated fibrinogen receptor) were determined in 20 pairs of women with preeclampsia/normotensive pregnant women and in 12 nonpregnant women, with the use of flow cytometry.
Results

Basal platelet expression of CD61, CD42a and CD62P, and adenosine diphosphate–stimulated CD62P expression were increased in women with preeclampsia compared with normotensive pregnant women. Platelets from women with preeclampsia and normotensive pregnant women differed from platelets from nonpregnant women by expressing higher basal CD63 levels and being more responsive to in vitro agonist stimulation, which was demonstrated by increased expression of CD61, CD62P, and CD63.
Conclusion

This study supports the notion that platelets are important in the pathophysiologic condition of preeclampsia.

Sumário (português)  :

Comments :

Argument (français) :

Argument (English):

Argumento (português):

Keywords :

➡ eclampsia (pre-)

Author of this record :

Cécile Loup — 29 Apr 2004

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This database is managed by Alliance francophone pour l'accouchement respecté (AFAR, https://afar.info)
affiliated with Collectif interassociatif autour de la naissance (CIANE, https://ciane.net).
It is fed by the voluntary contributions of persons interested in the sharing of scientific data.
If you agree with this project, you can support us in several ways:
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