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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 28 May 2004
Modified on : 01 Dec 2007

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Bibliographical entry (without author) :

Increased breath markers of oxidative stress in normal pregnancy and in preeclampsia. American Journal of Obstetrics and Gynecology 2004;190(5):1184-1190.

Author(s) :

Moretti M, Phillips M, Abouzeid A, Cataneo RN, Greenberg J.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :


The purpose of this study was to compare the intensity of oxidative stress in normal pregnancy, preeclampsia, and nonpregnant women using a breath test.

Study design

We studied primiparous women in third trimester pregnancy (38 uncomplicated, 26 with preeclampsia) and 60 nonpregnant control subjects. Volatile organic compounds (VOCs) in alveolar breath were analyzed by gas chromatography/mass spectroscopy to construct the breath methylated alkane contour (BMAC), a 3-dimensional display of abundance of C4-C20 alkanes and monomethylated alkanes.


The mean volume under curve (VUC) of the BMAC was significantly higher in preeclampsia patients than in normal pregnant women (P<.003) and nonpregnant control subjects (P<.005). A predictive model employing 5 VOCs distinguished preeclampsia from uncomplicated pregnancy (sensitivity = 92.3%, specificity = 89.7%; cross-validated sensitivity = 88.5%, specificity = 79.3%).


A breath test significantly demonstrated greater oxidative stress in women with preeclampsia than in uncomplicated pregnancy and nonpregnant control subjects. The breath test accurately identified women with established preeclampsia, but further studies are required to determine if this test can predict the onset of disease.

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Argument (English):

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Keywords :

➡ screening ; eclampsia (pre-)

Author of this record :

Cécile Loup — 28 May 2004

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