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Database - Alliance francophone pour l'accouchement respecté (AFAR)

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Created on : 27 Jul 2004
Modified on : 27 Dec 2007

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Bibliographical entry (without author) :

Risk of amniocentesis in women screened positive for Down syndrome with second trimester maternal serum markers. Prenat Diagn. 2002 Nov;22(11):1036-9.

Author(s) :

Muller F, Thibaud D, Poloce F, Gelineau MC, Bernard M, Brochet C, Millet C, Real JY, Dommergues M.

Year of publication :


URL(s) :…

Résumé (français)  :

Abstract (English)  :

In routine obstetrical practice, prior to offering invasive prenatal diagnosis, it is crucial to weigh the risks attendant on amniocentesis against the individual’s risk of aneuploidy. We took advantage of a policy of follow-up of patients undergoing Down syndrome maternal serum screening to compare the rates of fetal loss before 24 weeks and of early premature delivery at 24-28 weeks between women who underwent amniocentesis and women who did not.

A total of 54 902 patients entered the study, of whom 4039 (7.35%) were lost to follow-up and 387 were excluded because of a severe fetal abnormality. Of the 50 476 remaining patients, 3472 had an amniocentesis whereas 47 004 had not and served as controls.

In the amniocentesis group, the fetal loss rate before 24 weeks was 1.12% (95% CI=1.08-1.15) and the 24-28 weeks premature delivery rate was 0.40% (95% CI=0.39-0.41) which was significantly higher than in controls (0.42% with 95% CI 0.41-0.43 and 0.24% with 95% CI 0.23-0.25, respectively). The 0.86% difference in adverse outcome rates between the amniocentesis and control groups may be attributable to amniocentesis and compares favourably with the positive predictive value of maternal serum markers (1.70%) observed in the present study.

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Article en accès libre.

Argument (français) :

Evaluation des risques de l’amniocentèse chez des femmes dont le test sanguin au second semestre a été positif pour le syndrome de Down

Argument (English):

Argumento (português):

Argumento (español):

Keywords :

➡ premature baby ; amniocentesis ; screening ; stillbirth ; trisomy

Author of this record :

Cécile Loup — 27 Jul 2004

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